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Protocol Summary


Protocol No.
PSCI-17-068
Prinicipal Investigator
Schmitz, Kathryn
Phase
NA
Age Group
Adult
Scope
National
Secondary Protocol No.
FORCE
Title
FORCE: Focus on Reducing Dose-Limiting Toxicities in Colon Cancer with Resistance Exercise
Objective
Primary Objective:

To examine differences in dose reductions, dose delays and early stoppage for chemotherapy and the total combined number of moderate and severe chemotherapy-associated toxicities between intervention group and waitlist controls.

Secondary Objectives:

To examine specific inflammatory markers (e.g. CRP, IL-6, TNF-a receptor II [TNF-RII]) in relation to baseline MM and fat mass (FM) and examine differences in changes in inflammatory markers between intervention group and waitlist controls. Inflammatory markers and body composition will be measured pre and post intervention.

To examine the impact of RT induced body composition changes on the pharmacokinetics (PK) of 5-FU and oxaliplatin between baseline and 4 months of RT.
Applicable Disease Sites
Colon
Status
Open
Participating Institutions
Hershey Medical Center