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Protocol Summary


Protocol No.
PSCI-18-089
Prinicipal Investigator
Bluethmann, Shirley
Phase
N/A
Age Group
Adult
Scope
Local
Title
Using Exercise to Improve Arthralgia and AI Adherence in Older Breast Cancer Survivors
Objective
Study Objectives

The purpose of this pilot intervention study (n=76) is to test the effectiveness of a self-management approach (combining education- and exercise-based strategies) for improving AI-induced arthralgia in older breast cancer survivors (≥65 years).
Aim 1: Adapt an evidence-based PA intervention based on educational needs of older cancer survivors planning to take AIs. The steps will include; a) Conduct a needs assessment (short survey) with older survivors who are eligible for adjuvant hormonal therapy to develop educational content on AIs and arthralgia; b) Add a geriatric assessment to the curriculum for all participants; c) Conduct an open pilot to pre-test suitability of adapted module with potential users. Based on user feedback, the module will be revised prior to testing.
Aim 2: Test the effect of a pilot intervention on arthralgia and behavioral predictors for AI medication adherence (e.g., knowledge and self-efficacy).
Hypothesis 1: Participants in the treatment group will have less arthralgia/joint pain than controls.
Hypothesis 2: Participants in the treatment group will have more knowledge and better self-efficacy to use exercise to manage arthralgia than controls.
Aim 3: Test the effect of a pilot intervention on adherence to aromatase inhibitors.
Hypothesis 3: Participants in the treatment group will have better adherence than controls.
Applicable Disease Sites
Breast
Status
Open
Participating Institutions
Hershey Medical Center