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Protocol Summary


Protocol No.
PSHCI-12-109
Prinicipal Investigator
Belani, Chandra
Phase
NA
Age Group
Adult
Scope
Local
Title
Oncogenic Driver Mutations/Biomarkers in Screening Participants for Early Detection of Lung Cancer
Objective
Primary Objectives
To identify and validate Oncogenic Driver Mutations/Biomarkers for the early detection of lung cancer in individuals at high-risk for lung cancer. These mutations/biomarkers of interest include those seen in EGFR, k-ras, HER-2, BRAF, PI3KCA, DDR2, PTEN, TP53, RB1, CREBBP, EP300, SLIT2, MLL, EPHA7, and EML4/ALK gene rearrangement.

Secondary Objectives
To characterize the nodules and preneoplastic lesions in screening participants with presence/absence of Oncogenic Drivers Mutations/Biomarkers in an attempt to develop personalized approaches to management and follow-up. This will lead to individualizing therapy for these subjects at high- risk for development of lung cancer.
Applicable Disease Sites
Lung
Status
Open
Participating Institutions
Hershey Medical Center
Contact
Name
Xin Liu
Phone No.
+1 717-531-3073
E-mail
xliu2@pennstatehealth.psu.edu