Exon Sequencing of Cancer Associated Genes in Endometrial Hyperplasia
Primary Study Endpoints The primary endpoint is to determine if a series of endometrial hyperplasias found prior to a diagnosis of endometrioid adenocarcinoma of the uterus harbors mutations in the most commonly mutated genes found in endometrioid adenocarcinoma (e.g. PTEN, PIK3CA, KRAS, ARID1A, others). Associated is the endpoint to determine if endometrial hyperplasia that resolves spontaneously does no harbor mutations in these genes. Secondary Study Endpoints Once mutations in endometrial hyperplasia have been identified by exon sequencing, the corresponding endometrioid adenocarcinoma (if present) will be evaluated for these specific mutations by Sanger sequencing, to determine the clonal relationship between endometrial hyperplasia and the associated carcinoma.