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Protocol Summary


Protocol No.
PSHCI-14-077
Prinicipal Investigator
Drabick, Joseph
Phase
NA
Age Group
Adult
Scope
Local
Secondary Protocol No.
IRB# 00001324
Title
Definition of Somatic Variants Corresponding to Immune Targets in Patients with Metastatic Melanoma
Objective
To determine the feasibility of the detection and characterization of novel epitopes in FFPE tissues using adjacent normal tissues as controls
To determine if there are differences in the epitope expression between responders (long term survivors) and non-responders (rapid progressors) to immune therapy
To determine if there are differences in known genes of known importance to immunotherapies such as MHC Class I expression, PD-1L1, PD1-L2 expression and other phenotypes on immunohistochemical assays
Applicable Disease Sites
Melanoma, Skin
Status
Open
Participating Institutions
Hershey Medical Center