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Protocol Summary


Protocol No.
PSCI-16-094
Prinicipal Investigator
Zheng, Siyang
Phase
NA
Age Group
Adult
Scope
Local
Secondary Protocol No.
1DP2CA174508-01; RSG-13-009-01-CDD
Title
Collection of Blood for Investigation and Characterization of Circulating Tumor Cells (CTCs) in Cancer Patients with Microdevices
Objective
The purpose of the project is to develop microdevice based technology for circulating tumor cell (CTC) enrichment and analysis from blood samples of cancer patients.
The aims of the project include:
1. Design, fabricate, characterize, and optimize the system (device and its housing cassette) for viable CTC enrichment.
2. Demonstrate functional assays following CTC enrichment.
3. Demonstrate molecular analysis after CTC enrichment, for example high performance multi-marker qRT-PCR for CTC detection.
4. Develop primary CTC culture technology, for example by in situ (on-chip) culture or viable cell release (off-chip culture). As a proof of principle, demonstrate anti-cancer drug response of culture cells.
Applicable Disease Sites
Any Site

Unknown Sites
Status
Open
Participating Institutions
Hershey Medical Center

Penn State - University Park