Effect of oral black raspberry administration on oral cell DNA adducts in smokers
Objective
We will determine for the first time the effects of local black raspberry (BRB) delivery on formation of 1) covalent carcinogen-derived DNA adducts and 2) oxidative DNA damage (8-OXO-dG) in exfoliated oral keratinocytes and 3) systemic oxidative DNA damage (8-OXO-dG) in urine in current smokers. Based on preclinical data, we hypothesize that daily black raspberry administration will reduce the levels of DNA damage due to tobacco smoke exposure.
