Specimen Banking with Clinical and Genomic Data Registry with the Establishment of Tumor Models for Pediatric Cancers.
Objective
The primary objective of this study is to: Create a data registry of clinical and molecular/genomic data from cancer patients who have undergone biopsy or surgical resection for clinical care to better understand the relationship between genomic and molecular information and clinical outcomes: Define genomic landscape of pediatric cancers through the determination of the number and types of genomic alterations within tumor types/subtypes, across tumor types, and tumor evolution over time. Evaluate the rate of actionable genomic alternations resulting in associated targeted therapies relative to all actionable genomic alterations. Evaluate the correlation of baseline genomic alterations with clinical outcome.
The secondary objectives are to: Bank additional specimens available for future research projects. Create cell line and xenograft models of pediatric cancers for future research.
